Table 2 Circadian rhythm disorder in PD models

Mouse

MitoPark

Loss of dopamine leads to circadian alterations of the rest/activity cycle.

[272]

Mouse

A53T

Impaired light entrainment of the circadian system

[273]

Mouse

ASO

Diurnal and circadian rhythms of wheel running behavior are disrupted

[274]

Mouse

MPTP

Expression of Bmal1, Per1, Per2, Cry1, Dec1 and Rev-erbα shows decreased amplitude of circadian oscillation

[275]

Rat

6-OHDA

Endogenous circadian rhythm in constant darkness is disrupted.

[276]

Rat

6-OHDA

The mRNA levels of Bmal1, Per2, and Clock are decreased.

[277]

Rat

LPS or rotenone

The mRNA levels of Bmal1, Clock, Npas2, Per1 and Per2 are decreased.

[278]

Rat

6-OHDA

Rats housed in constant darkness are less active.

[279]

Rat

6-OHDA

The length of the locomotor activity period is decreased during the dark, and increased during the light period.

[280]

Rat

6-OHDA

Decreased amplitude of heart rate and heart rhythm

[281]

Rat

6-OHDA

The circadian rhythms of blood pressure and temperature are disrupted.

[282]

Monkey

MPTP

Loss of circadian locomotor activity in the absence of light/dark cues

[283]

Drosophila

pink1 and parkin mutants

The fragmentation of sleep, the anticipation of dawn

[12]

Drosophila

pink1 and parkin mutants

Weakened circadian rhythms in locomotor activity

[284]

Drosophila

TP-αS

TP-αS expression in neurons interferes with the circadian rhythm of aging flies

[285]

Zebrafish

MPP + 

Decreased activity, sleep disruptions, and impaired habituation to repetitive startles

[286]