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Table 1 Prevalence of sleep disorders in neurodegenerative diseases

From: Circadian disruption and sleep disorders in neurodegeneration

 

Sleep-wake disorder

Parasomnia

SDB

RLS

Insomnia

EDS

REM parasomnia

NREM parasomnia

RBD

Nightmares

PD

32%–44% [241,242,243]

21%–76% [27, 243]

39%–46% [242, 243]

17.2%–30% [241, 244]

Sleepwalking: (0.9%–1.8%) [158, 241]

Night terror: 3.9% [241]

NREM arousal-related disorder: 10.3% [245]

27.6%–48% [32, 246]

14% [57]

MSA

19% [247]

28% [248]

88% [249]

 

Stridor: 30%–42%

OSA:15%–37% [250]

4.7%–28% [251]

DLB

26%–75% [252]

11%–100% [252]

76% [112]

83% [252]

34.8%–60% [253]

PDD

72% [252]

83% [252]

17% [252]

78% [252]

   

FTD

48% [254]

64% [254]

Rare [254]

Rare [255]

68% [254]

8% [254]

CBD

Rare [256, 257]

14.3% [258]

Rare [259]

Rare [259]

PSP

60% [260]

60% [260]

11.4%–28% [258, 261]

55% [262]

3.7%–58% [263]

AD

40% [48]

45% [264]

Rare [265]

15%–54% [56, 63, 64]

4%–6% [55, 56]

HD

25%–51% [266, 267]

35.4%–50% [268, 269]

12%–25.8% [269, 270]

22.5% [269]

30.8% [271]

15.4%

& one family case report [60, 271]

  1. EDS excessive daytime sleepiness; RBD rapid eye movement (REM) sleep behavior disorder; NREM non-REM; SDB sleep-disordered breathing; RLS restless leg syndrome; PD Parkinson’s disease; MSA multiple system atrophy; DLB dementia with lewy bodies; FTD frontotemporal dementia; CBD corticobasal degeneration; PSP progressive supranuclear palsy; AD Alzheimer’s disease; HD Huntington’s disease; OSA obstructive sleep apnea