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Fig. 2 | Translational Neurodegeneration

Fig. 2

From: p85S6K sustains synaptic GluA1 to ameliorate cognitive deficits in Alzheimer’s disease

Fig. 2

p85S6K interacts with GluA1 specifically. a Co-immunoprecipitation of AMPA receptors in hippocampal tissue lysates with Flag-p85S6K or empty vector (Mock) from HEK293 cell lysates. b Co-immunoprecipitation of myc-GluA1 or myc-GluA2 with Flag-p85S6K, with AKAP79 co-transfected in HEK293 cells. c Co-immunoprecipitation results for Flag-p85S6K or Flag-p70S6K with myc-GluA1, with AKAP79 co-transfected in HEK293 cells. d, e Co-immunoprecipitation of endogenous GluA1 with p85S6K in the PSD-1 fraction. f Confirmation of such interaction in vivo by in situ PLA. Scale bar, 10 μm. Representative blots or images of at least 3 independent experiments are shown. IP immunoprecipitation, IB immunoblot

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