Fig. 1
From: Enhanced delivery of a low dose of aducanumab via FUS in 5×FAD mice, an AD model
FUS-mediated BBB opening significantly increased the delivery of Adu in the brain. a A scheme of the FUS system set up for BBB opening in mice. b A schematic diagram for unilateral (upper panel) and bilateral (lower panel) FUS sonication. c Pre- and post-gadolinium T1-weighted images: FUS-mediated BBB opening was confirmed with MRI. d FUS was treated unilaterally to the brains of experimental animals. A representative image of Western blotting with an antibody against human IgG after Adu injection and unilateral FUS treatment. e Representative confocal images (20x) of human IgG (Aducanumab), Aβ stained with 6E10 antibody and DAPI in the dentate gyrus of the hippocampus. f A bar graph showing the levels of Adu assessed with human IgG antibody in the hippocampus. Data are presented as mean ± SEM. Statistical analyses were performed using one-way ANOVA, followed by Tukey’s post hoc analysis. (****P < 0.0001, ***P < 0.001, n = 5 mice for each group)