Fig. 3
From: Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases
The therapeutic effects of stem cell-derived EVs on NDs.
To date, the therapeutic effects of EVs derived from MSCs, NSCs, NBCs, and SHEDs have been reported in various animal models of NDs. These stem cell-derived EVs carry Aβ degradation-related enzyme (e.g., NEP) and lipids (e.g., GSLs), growth factors, neurotrophic factors, therapeutic miRNAs. The administration of stem cell-derived EVs therefore improves cognitive/motor function, facilitates Aβ/α-syn clearance, enhances neuroprotection, suppresses neuroinflammation, promotes neuroregeneration of ND animal models