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Fig. 5 | Translational Neurodegeneration

Fig. 5

From: Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson’s disease dementia

Fig. 5

Neurofilament immunoreactivity correlates with decreased cortical thickness in PD and increased cortical MD in PDD/DLB. (a, b) Correlation of cortical p-NfM/H and (c, d) NfL immunoreactivity with cortical thickness on the left, and cortical MD on the right. Immunoreactivity of both neurofilaments correlated with decreased cortical thickness, specifically in PD, and with higher cortical MD, specifically in PDD/DLB. Every data point represents a cortical region of interest of a donor, and the groups are indicated by colours in the figure. For each group, the regression line is shown, together with its colour-coded standard error (pink for PD and brown for PDD/DLB). Significant correlations are highlighted in red bold in every panel. Legend: correlation significant at *P < 0.05, **P < 0.01, ***P < 0.001. DLB: Dementia with Lewy bodies; FWC-MD: free-water corrected mean diffusivity; MD: mean diffusivity; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain

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Translational Neurodegeneration

ISSN: 2047-9158

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