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Fig. 4 | Translational Neurodegeneration

Fig. 4

From: Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson’s disease dementia

Fig. 4

Cortical neurofilament immunoreactivity correlates with pSer129-αSyn and p-tau load. Correlation of (a and b) cortical p-NfM/H and (c and d) NfL immunoreactivity with pSer129-αSyn-positive LB count and p-tau load, respectively. Every data point represents a cortical region of a donor, and the groups are indicated by different colours. For each group, the regression line is shown, together with its colour-coded standard error (orange for controls, pink for PD and brown for PDD/DLB). Significant correlations are highlighted in bold red in the upper box in every panel. Legend: correlation significant at *P < 0.05, **P < 0.01, ***P < 0.001. DLB: Dementia with Lewy bodies; LB: Lewy Body; NfL: neurofilament light chain; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; p-NfM/H: phosphorylated neurofilament medium and heavy chain; p-tau: phosphorylated tau

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Translational Neurodegeneration

ISSN: 2047-9158

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