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Table 1 Subject demographics and neuropathological staging

From: Axonal degeneration in the anterior insular cortex is associated with Alzheimer’s co-pathology in Parkinson’s disease and dementia with Lewy bodies

ID & clinical diagnosis

Sex

Age death (years)

Disease duration (years)

CDR

Braak α-synuclein

Braak NFT & age-related tauopathy

Thal phase

CAA

PMD (h:min)

ABC score

PD_1

M

77

11

-

5

II

1

5:35

A1B1C0

PD_2

F

68

16

0.5

5

II

1

7:55

A1B1C0

PD_3

F

73

3

0

4

II, ARTAG

2

6:10

A1B1C0

PD_4

M

91

26

0.5

6

III, PART

3

Type I

4:00

A3B2C1

PD_5

M

57

16

5

0

1

-

06:35

A1B0C0

PDD_1

F

88

15

0.5

5

II, ARTAG and PART

0

05:35

A0B1C0

PDD_2

M

74

7

1

6

II, ARTAG

3

04:35

A2B1C0

PDD_3

F

74

13

1

6

III

3

Type II, grade 1

03:45

A2B2C1

PDD_4

F

81

8

0.5

6

II, ARTAG

3

Type I, grade 1

06:40

A2B1C1

PDD_5

M

75

6

0.5

6

II, ARTAG

1

03:35

A1B1C0

PDD_6

M

70

19

1

6

III, ARTAG

3

04:30

A2B2C0

PDD_7

F

88

6

0.5

6

II, ARTAG

1

06:05

A1B1C0

PDD_8

M

81

18

0.5

6

III, ARTAG & PART

0

06:10

A0B2C0

PDD_9

F

83

14

-

6

IV, ARTAG & PART

0

-

06:15

A0B2C0

PDD_10

M

71

26

3

5

II, ARTAG

1

13:50

A1B1C0

PDD_11

F

87

10

2

5

III, ARTAG

3

07:55

A2B2C0

PDD_12

M

94

18

3

6

III, ARTAG

2

Type II, stage 1

06:30

A1B2C1

PDD_13

M

75

12

1

5

II, ARTAG

0

12:25

A0B1C0

DLB_1

M

67

3

3

6

V, ARTAG

5

Type I

05:20

A3B3C3

DLB_2

M

75

2

3

6

III, ARTAG

4

05:00

A2B2C3

DLB_3

M

81

4

2

6

III

3

08:21

A2B2C0

DLB_4

M

78

6

1

6

I, ARTAG

3

Type II

05:10

A2B1C0

DLB_5

M

60

7

3

6

0

0

-

08:30

A0B0C0

DLB_6

M

70

5

-

6

III, ARTAG

4

Type I, grade 1

07:40

A3B2C1

DLB_7

M

71

9

6

II, ARTAG

3

Type I, grade 1

04:10

A2B1C1

DLB_8

F

77

4

3

6

V, ARTAG

4

Type I, stage 1

03:45

A3B3C3

DLB_9

F

67

3

3

5

III

4

Type II, stage 1

07:45

A3B2C1

  1. ABC score: A-C(0–3, A: Amyloid plaque score, B: Braak NFT score, C: CERAD neuritic plaque score), ARTAG Aging-related tau astrogliopathy, Braak NFT: 0-VI, Braak α-synuclein: 0–6, CAA Cerebral amyloid angiopathy (types: I (capillary) or II (capillary and arteriolar), stages 1–3), DLB Dementia with Lewy bodies, NFT Neurofibrillary tangles, PART Primary age-related tauopathy, PD Parkinson’s disease, PDD PD dementia, PMD Post-mortem delay, Thal phase: 0–5