Table 2 Number of rats (male/female), injected radioactivity, and dose for the pharmacokinetic (PK) and the PET studies
Radioligand | PK study | PET study | Injected radioactivity (MBq) | Injected dose (mg/kg) | ||
|---|---|---|---|---|---|---|
WT | WT | TgF344-AD | ||||
4 h | 70 h | 3 days | 3 days | |||
[124I]I-OX265F(ab′)2Bapi | ― | ― | 2/2 | 4/1 | 13.0 ± 6.1 | 0.12 ± 0.08 |
[125I]I-OX265F(ab′)2Bapi | 2/0 | 2/0 | ― | ― | 0.9 ± 0.1 | 0.04 ± 0.02 |
[124I]I-OX2676F(ab′)2Bapi | 2/0 | 3/0 | ― | ― | 6.1 ± 1.3 | 0.04 ± 0.01 |