Fig. 3
[124I]I-OX265-F(ab′)2-Bapi PET images and quantification. a Representative in vivo PET images from TgF344-AD and WT rats 3 days post-administration of [124I]I-OX265-F(ab′)2-Bapi. b PET image-based quantification of [124I]I-OX265-F(ab′)2-Bapi distribution (SUV) in WT and TgF344-AD rat brains. c Ex vivo [124I]I-OX265-F(ab′)2-Bapi retention (SUV) in WT and TgF344-AD rat brains. d Pearson’s correlation between PET-based quantification (SUVPET) and ex vivo retention (SUVex vivo) of [124I]I-OX265-F(ab′)2-Bapi in four brain regions from TgF344-AD rats. e Brain-to-blood ratio in TgF344-AD and WT rats. f Peripheral ex vivo biodistribution (SUV) of [124I]I-OX265-F(ab′)2-Bapi in TgF344-AD and WT rats 3 days post-administration. **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001