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Fig. 5 | Translational Neurodegeneration

Fig. 5

From: Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine

Fig. 5

Ceramides and gangliosides therapeutic strategies. Upper panel shows an overview of sphingolipid metabolism intervention points. Sphingolipids with neurotoxic effects and neuroprotective effects in ALS conditions are highlighted in salmon pink and green, respectively. Lower panels describe the toxicity and the therapeutic strategies used. a Selective inhibition of SPTCL1 variant allele, b fingolimod-mediated neuroprotection, c inhibition of glucosylceramide breakdown, and d ganglioside-mediated therapeutics. Intervening compounds, RNAs and antibodies are highlighted in orange

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