Why do ‘OFF’ periods still occur during continuous drug delivery in Parkinson’s disease?

Table 1 Reduction of daily ‘OFF’ time with rotigotine patch treatment

Study	Number of participants	Average follow-up duration (months)	Reduction of daily ‘OFF’ time (%)
LeWitt et al. [41]	168	6	37
Poewe et al. [44]	204	6	25
Nicholas et al. [33]	397	4	34
Mizuno et al. [42]	110	5	31
Nomoto et al. [43]	54	3	32
Zhang et al. [45]	170	3	34
Weighted average improvement in OFF time*			32.4

Data from controlled studies assessing the efficacy of rotigotine transdermal patch in reducing ‘OFF’ time in the treatment of patients with advanced disease. *Weighted for participant number per study

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