Fig. 2From: The emerging role of furin in neurodegenerative and neuropsychiatric diseasesActivities mediated by furin and its substrates in the brain. The substrates of furin include growth factors such as BDNF and NGF, proteases such as MMPs, ADAMs and BACE1, and receptors such as Notch, LRP1, GPR37, sortilin, BRI2 and Ac45. They participate in diverse biological processes in the brain, including neuronal survival and death, proliferation and differentiation, dendritic development, synaptic plasticity, inflammation and neurodegenerationBack to article page