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Fig. 1 | Translational Neurodegeneration

Fig. 1

From: Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease

Fig. 1

RT-QuIC detection of α-syn seeding activity in the nasal swabs (NSs) of patients with PD and non-PD. a Illustration of olfactory mucosa (OM) swab sampling from agger nasi (AN) (NSAN) and middle turbinate (MT) (NSMT) (created with BioRender.com). b Average thioflavin T (ThT) fluorescence from four replicate readings obtained in NS for each subject with PD (n = 43) and non-PD (n = 29) at 80 h. NSAN are shown as blue triangles (n = 46) while red dots denote NSMT (n = 26). c Traces represent the relative average percentage of ThT fluorescence readings from four replicate reactions (normalized as described in the Methods section) from PD and non-PD samples. The means (thick lines) with standard deviations (thin lines) are shown as a function of RT-QuIC reaction time

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