Fig. 6
From: Loss of tau expression attenuates neurodegeneration associated with α-synucleinopathy
Loss of tau delays α-synucleinopathy-associated spinal motor neuron degeneration in TgA53T mice. Spinal cord sections from end-stage (a–g) and 70-dpi (h–n) TgA53T mice and controls (nTg, mTau−/−) were stained for NeuN (neuronal marker). Shown are representative images of lumbar ventral horn region. In end-stage mice (a–g), TgA53T and TgA53T/mTau−/− mice show significant loss of ventral horn (V. Horn) motor neurons (a–e; F(3,26) = 82.45, P < 0.0001). NeuN quantification further demonstrated significant neurodegeneration within the ventral horn (f; F(3,20) = 21.75, P < 0.0001), but not dorsal horn (D. Horn) (g; F(3,20) = 1.257; P = 0.3160). At 70 dpi (h–n), ventral horn motor neuron degeneration (l; F(3,20) = 14.15, P < 0.0001) as well as ventral NeuN+ neuronal loss (m—Ventral: F(3,20) = 6.490, P = 0.0030; n—Dorsal: F(3,20) = 0.4447, P = 0.7237) was delayed with tau loss. Abbreviation: days post inoculation, dpi; One-way ANOVA with Tukey’s post-hoc analysis. n = 5–10 sections from 3 to 5 animals/genotype; scale bars = 100 μm; error bars represent mean ± SEM