Fig. 5
From: Loss of tau expression attenuates neurodegeneration associated with α-synucleinopathy
Loss of tau attenuates intermediate neuropathology in TgA53T mice. Spinal cord sections from 70-dpi nTg, mTau−/−, TgA53T, and TgA53T/mTau−/− mice were stained for pS129 αS (a–e), Iba1 (f–j), and GFAP (k–o). Shown are representative images and corresponding quantitative analysis of % area covered by immunoreactivity in the lumbar region. The indices of neuropathology were all significantly reduced in TgA53T/mTau−/− compared to TgA53T mice at 70 dpi. One-way ANOVA with Tukey’s post-hoc analysis. pS129 αS: F(3,23) = 82.46; P < 0.0001. Iba1: F(3,26) = 25.79; P < 0.0001. GFAP: F(3,18) = 69.86; P < 0.0001. n = 5–9 sections from 3 animals/genotype; scale bars = 100 μm; error bars represent mean ± SEM