Fig. 1

Effective conversion from human skin fibroblasts into neurons. Studies have determined an effective protocol for reprogramming human skin fibroblasts into neurons. First, fibroblasts are collected by skin biopsy from a human patient (a). Then, fibroblasts are cultured in a cell growth medium supplemented with chemical molecules inducing reprogramming into different types of neurons (b), such as glutamatergic, dopaminergic, GABAergic, and motor neurons. Furthermore, reports have suggested that this conversion is successfully evident at day 14, when neuronal features are observed, such as the presence of prolongations (dendrites and axons) and neuronal soma, along with physiological neuronal features (c) that represent brain function (d)