Fig. 8
From: N-terminally truncated Aβ4-x proteoforms and their relevance for Alzheimer’s pathophysiology
Intracerebral injection and brain clearance of full-length and truncated Aβ proteoforms. a Autoradiogram following electrophoretic separation of monomeric and 24-h-aggregated/oligomeric preparations of [125I]-labeled Aβ homologs on 16.5% SDS–polyacrylamide gels illustrates oligomerization profiles of the different Aβ forms prior to the intracerebral injection. b Schematic of the needle location for the intra-cerebral injection of the different Aβ proteoforms. c Brain clearance of radiolabeled full-length and truncated Aβ species in their monomeric conformations or after 24-h oligomerization. In all cases, bars illustrate percentage cleared relative to the total injected radioactivity; values represent mean ± SD obtained from inoculation of 5–9 mice (t-test, *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001)