Skip to main content
Fig. 1 | Translational Neurodegeneration

Fig. 1

From: N-terminally truncated Aβ4-x proteoforms and their relevance for Alzheimer’s pathophysiology

Fig. 1

Aβ immunohistochemistry in AD frontal cortex. Four Aβ antibodies were used on sequential sections to investigate the presence of different Aβ proteoforms in AD pathological lesions. On low-magnification images (ad), Aβ antibodies targeting positions Aβ8-17, Aβx-42, Aβ4-x, and Aβx-40 all stained plaques and CAA deposits, although the latter displayed lower immunoreactivity. At higher magnification, all Aβ peptides were observed in CAA (e–h) and in cored plaques (il). Diffuse plaques, however, showed an abundance of Aβ8-17, Aβx-42 and Aβ4-x reactivity (panels m, o, and p, respectively) with only sparse Aβx-40 staining (n). All images were acquired from Case 2. Scale bar in a represents 100 µm in (ad); scale bar in e represents 50 µm (ep)

Back to article page