Fig. 8
From: Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease
Melatonin alters the miRNA expression profile in hTau mice. MiRNA sequencing in the hippocampal tissues from hTau mice treated with saline or melatonin was performed using microarray (male, n = 3/group). The identified differentially expressed miRNAs between the two groups are displayed in the heatmap (a) and the volcano plot (b) (fold change > 2, P < 0.04). The mean fluorescence intensity was calculated as the average of three replicates. Eleven miRNAs were upregulated, while five miRNAs were downregulated. c The relative expression of miR-504-3p in the hTau mice treated with melatonin was confirmed by qRT-PCR. Data are presented as the means ± standard errors (****P < 0.0001 vs. the hTau + SA group)