Table 2 Age and genotype statistics for entorhinal cortical and hippocampal inhibitory interneuron changes
Readout | Age effect | Genotype effect | AgeXgenotype interaction | 9-month: NTg-Tg | 12-month: NTg-Tg | 15-month: NTg-Tg |
|---|---|---|---|---|---|---|
HP non-cell layer NeuN (Fig. 2a) | F(2,46) = 0.44; P = 0.65 | F(1,46) = 5.90; *P = 0.02 | F(2,46) = 0.72; P = 0.49 | P = 0.55 | P = 0.07 | P = 0.55 |
HP GAD67 (Fig. 2d) | F(2,43) = 11.35; ***P = 0.0001 | F(1,43) = 0.02; P = 0.89 | F(2,43) = 9.22; ***P = 0.0005 | P = 0.13 | **P = 0.004 | P = 0.10 |
HP molecular layer GAD67 (Fig. 2e) | F(2,43) = 21.35; ***P < 0.0001 | F(1,43) = 0.04; P = 0.84 | F(2,43) = 10.55; ***P = 0.0002 | P = 0.15 | ***P = 0.001 | P = 0.11 |
HP hilus GAD67 (Fig. 2f) | F(2,43) = 2.83; P = 0.07 | F(1,43) = 28.97; ***P < 0.0001 | F(2,43) = 3.55; *P = 0.04 | ***P < 0.0001 | P = 0.29 | **P = 0.002 |
HP GCL GAD67 (Fig. 2g) | F(2,43) = 4.07; *P = 0.02 | F(1,43) = 0.03; P = 0.87 | F(2,43) = 2.15; P = 0.13 | N/A | N/A | N/A |
EC GAD67 (Fig. 2h) | F(2,43) = 5.05; **P = 0.01 | F(1,43) = 7.23; **P = 0.01 | F(2,43) = 0.88; P = 0.42 | P = 0.12 | P = 0.62 | P = 0.10 |
EC layer II GAD67 (Fig. 2i) | F(2,43) = 2.69; P = 0.08 | F(1,43) = 1.60; P = 0.21 | F(2,43) = 0.20; P = 0.82 | N/A | N/A | N/A |