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Table 2 Age and genotype statistics for entorhinal cortical and hippocampal inhibitory interneuron changes

From: Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer’s disease

Readout Age effect Genotype effect AgeXgenotype interaction 9-month: NTg-Tg 12-month: NTg-Tg 15-month: NTg-Tg
HP non-cell layer NeuN
(Fig. 2a)
F(2,46) = 0.44;
P = 0.65
F(1,46) = 5.90;
*P = 0.02
F(2,46) = 0.72;
P = 0.49
P = 0.55 P = 0.07 P = 0.55
HP GAD67
(Fig. 2d)
F(2,43) = 11.35;
***P = 0.0001
F(1,43) = 0.02;
P = 0.89
F(2,43) = 9.22;
***P = 0.0005
P = 0.13 **P = 0.004 P = 0.10
HP molecular layer GAD67
(Fig. 2e)
F(2,43) = 21.35;
***P < 0.0001
F(1,43) = 0.04;
P = 0.84
F(2,43) = 10.55;
***P = 0.0002
P = 0.15 ***P = 0.001 P = 0.11
HP hilus GAD67
(Fig. 2f)
F(2,43) = 2.83;
P = 0.07
F(1,43) = 28.97;
***P < 0.0001
F(2,43) = 3.55;
*P = 0.04
***P < 0.0001 P = 0.29 **P = 0.002
HP GCL GAD67
(Fig. 2g)
F(2,43) = 4.07;
*P = 0.02
F(1,43) = 0.03;
P = 0.87
F(2,43) = 2.15;
P = 0.13
N/A N/A N/A
EC GAD67
(Fig. 2h)
F(2,43) = 5.05;
**P = 0.01
F(1,43) = 7.23;
**P = 0.01
F(2,43) = 0.88;
P = 0.42
P = 0.12 P = 0.62 P = 0.10
EC layer II GAD67
(Fig. 2i)
F(2,43) = 2.69;
P = 0.08
F(1,43) = 1.60;
P = 0.21
F(2,43) = 0.20;
P = 0.82
N/A N/A N/A
  1. Two-way ANOVA with correction for multiple comparisons (genotype differences per age) with a Holm-Sidak post hoc test
  2. EC entorhinal cortex, GAD67 glutamate decarboxylase 67, GCL granular cell layer, HP hippocampus, NeuN neuronal nuclei, NTg non-transgenic, Tg transgenic
  3. Significant effects are in bold text. *P < 0.05; **P < 0.01; ***P < 0.001