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Fig. 7 | Translational Neurodegeneration

Fig. 7

From: Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer’s disease

Fig. 7

TgF344-AD rats exhibit cognitive resilience at 12 months of age and cognitive loss at 9 and 15 months. NTg and TgF344-AD rats were tested for spatial learning, memory and executive function in the Barnes maze at 9 (n = 13 and 17), 12 (n = 12 and 14) and 15 (n = 14 and 17) months of age. The latency to escape and the complexity of search strategies utilized were assessed in spatial memory probe test, and during 5 days of reversal learning. At 9 months, no differences were detected in the spatial memory latency to escape (a) or the search strategy complexity (b). Tg rats exhibited impaired executive function at 9 months, with significantly longer latency to escape (c) and less complex strategies (d) in reversal trials. The 12-month-old Tg rats had impaired spatial memory, with no deficits in the latency to escape (e), but significant deficits in search strategy complexity (f). g and h Despite prior deficits, the 12-month-old Tg rats exhibited cognitive maintenance in executive function, and cognitive flexibility, with no significant genotype effects. At 15 months of age, significant Tg deficits were detected in spatial memory latency to escape (i), but not search strategy complexity (j). (k and l) Robust deficits were detected in executive function and cognitive flexibility at 15 months. Data are mean ± SEM; unpaired t-test (a, e, and i), Mann–Whitney U test (b, f, and j), repeated measures ANOVA with Holm-Sidak post hoc test (c, d, g, h, k, and l); *P < 0.05, **P < 0.01, ***P < 0.001

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