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Table 4 Selected functional, quality of life, caregiver burden and global impression outcomes

From: Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations

Outcome

Type of measure

Rater

Reliability

Responsiveness

MCID

Used in DLB trials

ADCS-ADL

ADLs

Informant

 + 

 + 

2 points

Yes [44,45,46]

DAD

ADLs

Informant

 + 

 + 

NE

Yes [40, 47]

UPDRS-II

ADLs

Informant

Subject

NE

NE

NE

Yes [48, 49]

SEADL

ADLS

Informant

NE

NE

NE

No

QOL-AD

QoL

Subject

 + 

 + 

NE

Yes [32]

PDQ-39

QoL

Subject

+/−

NE

NE

No

ZBI

CB

Informant

+/−

 + 

13 points

Yes [43, 45, 47, 50,51,52,53]

RSS

CB

Informant

 + 

NE

NE

No

CIBIC+

IoC

Clinician/Informant

+/−

 + 

NE

Yes [43, 54,55,56,57,58]

CGI

IoC

Clinician

+/−

 + 

NE

Yes [54, 59, 60]

ADCS-CGIC

IoC

Clinician

+/−

 + 

1 point

Yes [44, 45, 61, 62]

  1. +, good/adequate; +/−, acceptable; −, performance is questionable/mediocre. ADLs activities of daily living, CB caregiver burden, IoC impression of change, MCID minimal clinically important difference, NE not evaluated, QoL quality of life, ADCS-ADL Alzheimer’s Disease Cooperative Study—Activities of Daily Living Scale, DAD Disability Assessment for Dementia, UPDRS-II Unified Parkinson’s Disease Rating Scale Part II, SEADL Schwab and England Activities of Daily Living, QOL-AD Quality of Life in Alzheimer’s Disaese Scale, PDQ-39 39-Item Parkinson’s Disease Questionnaire, ZBI Zarit Burden Interview, RSS Relative Stress Scale, CIBIC+ Clinician’s Interview-Based Impression of Change Scale, CGI Clinical Global Impression Scale, ADCS-CGI Alzheimer’s Disease Cooperative Study–Clinician’s Global Impression of Change