Fig. 2

TDP-43 mice exhibited progressive brain atrophy. a Tensor-based morphometry analysis revealed foci of significant atrophy in TDP-43 mice (n = 7) compared to littermate controls (n = 5) at 3 weeks after the cessation of Dox feed. Results are shown overlaid on the Waxholm Space adult C57BL/6 J mouse brain atlas (top row), a 3D volume render (left, bottom) and glass brain (middle and right, bottom). The color bar shows FWE-corrected P-value. b–e Region-of-interest analysis demonstrated significant interactions between group and time in the neocortex (P = 0.0011) and hippocampus (P = 0.0207). No significant differences were observed for the whole brain or hypothalamus. ^###P < 0.001, main effect of time off Dox