Pathophysiological significance of increased α-synuclein deposition in sympathetic nerves in Parkinson’s disease: a post-mortem observational study

Table 2 Tissue catechol contents in control (CTRL) and PD groups

Parameter	CTRL	PD	P value
Scalp skin
NE (pmol/mg)	0.415 ± 0.058 (12)	0.387 ± 0.054 (14)	0.8201
DA (pmol/mg)	0.026 ± 0.010 (12)	0.031 ± 0.009 (9)	*
DHPG (pmol/mg)	0.016 ± 0.005 (12)	0.007 ± 0.001 (12)	0.0501
DOPAC (pmol/mg)	0.017 ± 0.003 (11)	0.011 ± 0.002 (14)	0.1492
SMG
NE (pmol/mg)	4.851 ± 0.656 (12)	5.296 ± 0.674 (14)	0.4624
DA (pmol/mg)	0.251 ± 0.100 (12)	0.254 ± 0.071 (14)	0.8596
DHPG (pmol/mg)	0.387 ± 0.068 (12)	0.495 ± 0.117 (14)	0.5952
DOPAC (pmol/mg)	0.060 ± 0.019 (12)	0.096 ± 0.030 (14)	0.6308
Myocardium
NE (pmol/mg)	1.322 ± 0.246 (12)	0.108 ± 0.056 (14)	< 0.0001
DA (pmol/mg)	0.138 ± 0.055 (12)	0.006 ± 0.003 (8)	*
DHPG (pmol/mg)	0.036 ± 0.011 (11)	0.004 ± 0.001 (9)	*
DOPAC (pmol/mg)	0.032 ± 0.011 (12)	0.006 ± 0.001 (14)	0.0056

Mean ± SEM. Numbers in parentheses are numbers of data points. Listed P values are for the non-parametric Mann–Whitney test. (*) indicates statistical testing not done, due to missing data points
DA = dopamine, DHPG = 3,4-dihydroxyphenylglycol, DOPAC = 3,4-dihydroxyphenylacetic acid, NE = norepinephrine, SMG = submandibular gland

ISSN: 2047-9158