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Table 1 Immunofluorescence signal intensities and related ratios in control (CTRL) and PD groups

From: Pathophysiological significance of increased α-synuclein deposition in sympathetic nerves in Parkinson’s disease: a post-mortem observational study

Parameter

CTRL

PD

P value

Scalp skin

Arrector pili muscles

 α-Syn intensity

0.861 ± 0.149 (12)

4.938 ± 0.533 (13)

 < 0.0001

 α-Syn/SMA

0.025 ± 0.004 (12)

0.156 ± 0.012 (13)

 < 0.0001

Blood vessels

 α-Syn intensity

1.187 ± 0.241 (12)

4.571 ± 0.482 (14)

 < 0.0001

 α-Syn/SMA

0.057 ± 0.010 (12)

0.213 ± 0.015 (14)

 < 0.0001

Sweat glands

 α-Syn intensity

1.112 ± 0.302 (11)

4.324 ± 0.661 (11)

 < 0.0001

 α-Syn/SMA

0.075 ± 0.017 (11)

0.246 ± 0.028 (11)

 < 0.0001

SMG

α-Syn intensity (× 105)

0.486 ± 0.159 (12)

16.932 ± 5.322 (14)

0.0011

α-Syn/SMA

0.007 ± 0.002 (12)

0.123 ± 0.034 (14)

0.0003

Myocardium

α-Syn intensity (× 105)

0.455 ± 0.202 (12)

4.999 ± 1.231 (14)

0.0011

α-Syn/cTnT

0.002 ± 0.001 (12)

0.020 ± 0.005 (14)

0.0007

Scalp skin

Arrector pili muscles

 TH intensity

11.438 ± 0.737 (12)

12.256 ± 1.149 (13)

0.3760

 TH/SMA

0.332 ± 0.023 (12)

0.406 ± 0.039 (13)

0.2051

 α-Syn/TH

0.075 ± 0.012 (12)

0.407 ± 0.028 (13)

 < 0.0001

Blood vessels

 TH intensity

6.084 ± 0.606 (12)

7.250 ± 0.676 (14)

0.2682

 TH/SMA

0.338 ± 0.057 (12)

0.344 ± 0.026 (14)

0.4319

 α-Syn/TH

0.225 ± 0.049 (12)

0.647 ± 0.044 (14)

 < 0.0001

Sweat glands

 TH intensity

5.688 ± 1.011 (11)

6.842 ± 0.821 (11)

0.3000

 TH/SMA

0.405 ± 0.082 (11)

0.418 ± 0.057 (11)

0.6522

 α-Syn/TH

0.189 ± 0.031 (11)

0.735 ± 0.141 (11)

 < 0.0001

 Coloc. Index

1.076 ± 0.196 (12)

2.278 ± 0.099 (14)

 < 0.0001

SMG

TH intensity (× 106)

4.010 ± 0.531 (12)

2.756 ± 0.509 (14)

0.1448

TH/SMA

0.555 ± 0.084 (12)

0.317 ± 0.048 (14)

0.0407

α-Syn/TH

0.017 ± 0.007 (12)

0.537 ± 0.198 (14)

 < 0.0001

Coloc. Index

0.885 ± 0.263 (12)

2.612 ± 0.331 (14)

0.0003

Myocardium

TH intensity (× 106)

2.280 ± 0.373 (12)

0.789 ± 0.157 (14)

0.0008

TH/cTnT

0.080 ± 0.011 (12)

0.031 ± 0.006 (14)

0.0005

α-Syn/TH

0.024 ± 0.011 (12)

0.810 ± 0.208 (14)

 < 0.0001

Coloc. Index

0.669 ± 0.219 (12)

0.909 ± 0.263 (14)

0.4700

  1. Mean ± SEM. Numbers in parentheses are numbers of data points. Listed P values are for the non-parametric Mann–Whitney test
  2. α-Syn = α-synuclein, Coloc. Index = α-synuclein-tyrosine hydroxylase colocalization index, cTnT = cardiac troponin T, SMA = smooth muscle actin, SMG = submandibular gland, TH = tyrosine hydroxylase
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Translational Neurodegeneration

ISSN: 2047-9158

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