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Fig. 2 | Translational Neurodegeneration

Fig. 2

From: Pathophysiological significance of increased α-synuclein deposition in sympathetic nerves in Parkinson’s disease: a post-mortem observational study

Fig. 2

Individual values and means ± SEM for immunoreactive signal intensities of α-synuclein (α-syn) and tyrosine hydroxylase (TH) and for concentrations of norepinephrine (NE, pmol/mg wet weight) in control (CTRL) subjects (gray) and PD patients (red). In each panel, linear (left) and logarithmic scales (right) are used. (ac) α-Syn intensities in arrector pili muscles, submandibular gland (SMG), and myocardium. (df) TH signal intensities in these tissues, and (gi) NE concentrations. Note α-syn intensities were increased in all 3 tissues in the PD group compared to the CTRL group (ac). Myocardial TH intensity was moderately decreased (f), and myocardial NE was substantially decreased (i) in the PD group. The groups did not differ in contents of TH or NE in skin (d, g) or SMG (e, h). (*) P < 0.005, (**)P < 0.0001 for PD vs. CTRL. n.s. non-significant difference

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