Fig. 1

Representative immunofluorescence confocal microscopic images from a control subject (CTRL) and a PD patient. Immunoreactive tyrosine hydroxylase (TH) indicates sympathetic noradrenergic innervation in an arrector pili muscle in scalp skin tissue (a), in submandibular gland (SMG, (b)), and in myocardium (c). Green shows α-synuclein (α-syn), and red shows TH. Blue shows smooth muscle actin (arrector pili muscles and SMG) or cardiac troponin T (cTnT, myocardium). The regions surrounded by white squares are magnified in the inserted images. Note increased α-syn deposition in arrector pili muscle, SMG, and myocardium in the PD patient but not in the CTRL subject