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Fig. 4 | Translational Neurodegeneration

Fig. 4

From: Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model

Fig. 4

Long-term hyperglycemia causes degeneration of dopaminergic neuronal profile in α-syn-overexpressing mice. (a) Western blot analyses of TH, DAT and NeuN protein levels in mouse SNpc. (b–d) Quantification of TH, DAT and NeuN protein levels (n = 3 to 4 mice/group). (e) Representative coronal mesencephalic sections with immunohistochemical staining of TH in the SN. (f) High-magnification images corresponding to the SNpc area indicated in (e4), (e7), and (e8). (g) Quantitative analyses of TH-positive neurons determined by stereology in the midbrain region. WT + vehicle (n = 4/4 mice at one/three months after injections, respectively); WT + STZ (n = 5/3 mice at one/three months after injections, respectively); α-syn + vehicle (n = 4/4 mice at one/three months after injections, respectively); α-syn + STZ (n = 4/3 mice at one/three months after injections, respectively). Scale bars, 50 µm. *P < 0.05, **P < 0.01, ***P < 0.001

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