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Fig. 3 | Translational Neurodegeneration

Fig. 3

From: Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model

Fig. 3

Long-term hyperglycemia aggravates motor deficits in α-syn-overexpressing mice. Motor performance at one and three months after injections in the pole test (a, b) and open field test (cf). T-turn (a) and T-total (b) increased in the STZ-treated α-syn compared to vehicle. (cf) In the open field test that assesses the spontaneous activity of mice, the mean speed in total zone (c), the total distance (d), the distance in the central zone (e) and the distance in the peripheral zone (f) differed between the α-syn + STZ and WT + vehicle groups. At least three mice were included in each group. The number of mice per group was provided in Additional file 1: Table S1. *P < 0.05, ***P < 0.001, ****P < 0.0001

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