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Fig. 2 | Translational Neurodegeneration

Fig. 2

From: Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model

Fig. 2

STZ treatment exacerbates structural damage of islets in α-syn-overexpressing mice compared to WT. (a) Representative microscopic images of immunohistochemical staining with antibody against insulin at one and three months after injections, in the pancreatic islets of WT + vehicle, WT + STZ, α-syn + vehicle and α-syn + STZ groups. (b) Quantification of average percentage of islet β-cell area to the total islet area in pancreas of WT and BAC-α-syn-GFP mice with i.p. injections of STZ or vehicle (n = 3 to 4 mice/group). Scale bar, 50 µm. *P < 0.05, ***P < 0.001, ****P < 0.0001

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