Domain-drug complex | ITrans | PTrans | IInter | PInter | IBump | PBump |
---|---|---|---|---|---|---|
N-term | – | – | – | – | − 30 ± 1 pA | 70% ± 2% |
N-term + CPA | −66 ± 6 pA | 35% ± 3% | – | – | − 26 ± 1 pA | 46% ± 2% [***] |
N-term + DPCPX | −72 ± 7 pA | 36% ± 10% | − 51 ± 2 pA | 21% ± 12% | − 30 ± 2 pA | 41% ± 1% [***] |
C-term | −69 ± 2 pA | 77% ± 4% | – | – | − 30 ± 2 pA | 20% ± 3% |
C-term + CPA | −66 ± 3 pA | 70% ± 8% [ns] | – | – | − 38 ± 4 pA | 23% ± 3% [ns] |
C-term + DPCPX | −64 ± 1 pA | 38% ± 2% [***] | − 31 ± 1 pA | 33% ± 4% | − 19 ± 1 pA | 7% ± 1% [ns] |
ΔNAC | −86 ± 2 pA | 58% ± 2% | – | – | − 27 ± 1 pA | 19% ± 4% |
ΔNAC + CPA | – | – | − 36 ± 3 pA | 66% ± 3% | – | – |
ΔNAC + DPCPX | – | – | − 39 ± 1 pA | 35% ± 5% | − 24 ± 2 pA | 34% ± 3% |