Table 1 Populations and blockade times of translocations and bumping events for α-syn alone and α-syn complexes with adenosine, CPA, and DPCPX
Protein-drug complex | α-syn | α-syn + Adenosine | α-syn + CPA | α-syn + DPCPX |
|---|---|---|---|---|
Population of translocation | 66% | 52% [*] | 40% [**] | 37% [**] |
SEM | 1% | 2% | 1% | 1% |
Population of bumping | 24% | 25% [ns] | 37% [**] | 46% [**] |
SEM | 1% | 3% | 2% | 2% |
Time of translocation | 0.52 ms | 0.46 ms [ns] | 0.47 ms [ns] | 0.42 ms [ns] |
SEM | 0.05 ms | 0.05 ms | 0.05 ms | 0.04 ms |
Time of bumping | 0.05 ms | 0.12 ms [***] | 0.09 ms [**] | 0.07 ms [*] |
SEM | < 0.01 ms | 0.01 ms | < 0.01 ms | < 0.01 ms |