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Fig. 2 | Translational Neurodegeneration

Fig. 2

From: LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease

Fig. 2

Vicious cycle of GCase deficiency and α-syn accumulation is associated with multiple defects in autophagic-lysosomal pathway. Reduced GCase activity leads to accumulation of its substrate GlcCer, which acts as a scaffold for α-syn fibril formation. α-Syn aggregation impairs the transport of GCase from ER to lysosome, further reducing lysosomal GCase activity

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