Fig. 2From: LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's diseaseVicious cycle of GCase deficiency and α-syn accumulation is associated with multiple defects in autophagic-lysosomal pathway. Reduced GCase activity leads to accumulation of its substrate GlcCer, which acts as a scaffold for α-syn fibril formation. α-Syn aggregation impairs the transport of GCase from ER to lysosome, further reducing lysosomal GCase activityBack to article page