Table 1 Local delivery routes of exogenous BDNF

Intrahippocampal infusion

Rats

Hippocampus

BDNF-containing PBS

Improves lasting potentiation of synaptic function in the dentate gyrus

[416]

DG

BDNF (no detailed information)

Increases neurogenesis of DG; most new neurons appear to become granule cells

[417]

vHPC

BDNF dissolved in PBS

Increases excitability in infralimbic targets and supports extinction memories

[411]

CA1

BDNF-containing sterile saline

Reverses the impairments in memory persistence; generates persistent LTM storage via activation of ERK

[407]

Intracortical infusion

Rats

dmPFC

BDNF-containing PBS

Alleviates cocaine-induced decrease in basal extracellular glutamate; reduces cocaine-mediated increase in extracellular glutamate with the NAc

[408]

Inhibits cocaine-induced phosphorylation of ERK and CREB

[409]

Mice

vmPFC

BDNF reconstituted in 0.9% saline

Rescues paradoxical reversal learning enhancement induced by stress or prefrontal cortical damage

[410]

Intra-nucleus accumbens injection

Rats

Nucleus accumbens

BDNF dissolved in saline

Suppresses dopamine release and dopamine-related behaviors induced by methamphetamine

[412]

Intranasal delivery

Rats

Nasal cavity

¹²⁵I-BDNF dissolved in sterile PBS

Intranasal delivery of 70 μg [¹²⁵I]-radiolabeled BDNF results in 1.6–25.1 ng/ml within 25 min in brain parenchyma

[418]

BDNF reconstituted in sterile PBS

Alleviates cerebral local inflammation induced by ischemia/reperfusion

[414]

BDNF-containing saline

Improves visual depth perception in amblyopic rats

[413]

Intracochlear infusion

Cats

Cochlear

BDNF-containing sterile artificial perilymph

Increases the total volume of cochlear nucleus to exert neurotrophic effects

[407]

Guinea pigs

BDNF-containing saline with BSA (1%)

Enhanced survival of spiral ganglion cells

[450]