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Fig. 5 | Translational Neurodegeneration

Fig. 5

From: Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

Fig. 5

Kaplan Meier curves of clinical progression to significant cognitive impairment (MMSE score < 20) in FTD (a) and AD (b) individuals with low, medium or high baseline pGFAP level. Red lines show the lowest tertile (below 154 pg/ml in FTD and below 228 pg/ml in AD), green lines show medium tertile (154–240 pg/ml in FTD and 226–366 pg/ml in AD), and blue lines show the highest tertile of biomarker concentrations (above 240 pg/ml in FTD and above 366 pg/ml in AD). In FTD, the median time of progression to significant cognitive impairment was 3.4 (0.87.0) years in the medium-tertile pGFAP group and 1.1 (0–2.3) years in the high-tertile pGFAP group (Log-rank test, P < 0.0001). pGFAP, plasma glial fibrillary acidic protein; FTD, frontotemporal dementia; AD, Alzheimer’s disease

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