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Table 3 Global and regional 18F-Florbetaben SUVR

From: Extensive frontal focused ultrasound mediated blood–brain barrier opening for the treatment of Alzheimer’s disease: a proof-of-concept study

  Case 1 Case 2 Case 3 Case 4 Case 5 Mean (SD)
Visit 1 Visit 8 Visit 1 Visit 8 Visit 1 Visit 8 Visit 1 Visit 8 Visit 1 Visit 8 Visit 1 Visit 8 P value
Global SUVR 2.172 2.277 (+ 4.8%) 1.876 1.901 (+ 1.3%) 1.955 1.972 (+ 0.9%) 1.722 1.648 (− 4.3%) 1.959 1.941 (− 0.9%) 1.937 (0.163) 1.948 (0.224)
(+ 0.6%)
0.686
Frontal SUVR 2.211 2.287 (+ 3.4%) 1.803 1.815 (+ 0.6%) 1.904 1.913 (+ 0.5%) 1.808 1.728 (− 4.4%) 1.955 1.896 (− 3.0%) 1.936 (0.167) 1.928 (0.214)
(− 0.4%)
0.893
Frontal/Other SUVR 1.034 1.008 (− 2.5%) 0.935 0.925 (− 1.1%) 0.953 0.946 (− 0.7%) 1.091 1.089 (− 0.2%) 0.996 0.963 (− 3.3%) 1.002 (0.063) 0.986 (0.065)
(− 1.6%)
0.043
  1. Wilcoxon signed rank test was used for comparing Visit 1 (baseline) and Visit 8 (3 months post-FUS)
  2. SUVR standardized uptake value ratio