Extensive frontal focused ultrasound mediated blood–brain barrier opening for the treatment of Alzheimer’s disease: a proof-of-concept study

Table 3 Global and regional ¹⁸F-Florbetaben SUVR

	Case 1		Case 2		Case 3		Case 4		Case 5		Mean (SD)
	Visit 1	Visit 8	Visit 1	Visit 8	Visit 1	Visit 8	Visit 1	Visit 8	Visit 1	Visit 8	Visit 1	Visit 8	P value
Global SUVR	2.172	2.277 (+ 4.8%)	1.876	1.901 (+ 1.3%)	1.955	1.972 (+ 0.9%)	1.722	1.648 (− 4.3%)	1.959	1.941 (− 0.9%)	1.937 (0.163)	1.948 (0.224) (+ 0.6%)	0.686
Frontal SUVR	2.211	2.287 (+ 3.4%)	1.803	1.815 (+ 0.6%)	1.904	1.913 (+ 0.5%)	1.808	1.728 (− 4.4%)	1.955	1.896 (− 3.0%)	1.936 (0.167)	1.928 (0.214) (− 0.4%)	0.893
Frontal/Other SUVR	1.034	1.008 (− 2.5%)	0.935	0.925 (− 1.1%)	0.953	0.946 (− 0.7%)	1.091	1.089 (− 0.2%)	0.996	0.963 (− 3.3%)	1.002 (0.063)	0.986 (0.065) (− 1.6%)	0.043

Wilcoxon signed rank test was used for comparing Visit 1 (baseline) and Visit 8 (3 months post-FUS)
SUVR standardized uptake value ratio

ISSN: 2047-9158