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Table 2 Feasibility of blood–brain barrier (BBB) opening as assessed by post-procedure MRI

From: Extensive frontal focused ultrasound mediated blood–brain barrier opening for the treatment of Alzheimer’s disease: a proof-of-concept study

 

Volume (cm3)*

Ratio of BBB opening to target (%)

Case 1

17.7

78.9

Case 2

20.0

100

Case 3

20.6

100

Case 4

22.6

97.6

Case 5

24.7

100

Mean (SD)

21.1 (2.7)

95.7 (9.4)

  1. *An average volume of two sessions of BBB opening
  2. An average ratio of BBB opening area to target