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Fig. 3 | Translational Neurodegeneration

Fig. 3

From: Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer’s disease

Fig. 3

Distribution of secretory proteins in the AD cerebral cortex. a Representative peroxidase immunohistochemistry for different secretory proteins in senile plaques at the superficial layers of the AD parietal cortex. Dystrophic neurite-like structures are indicated by arrows. Scale bar 20 µm. b In the same cortical senile plaques, AT8 immunofluorescence reveals PC2+ and SgIII aberrant structures as dystrophic neurites. Arrows indicate colocalization in yellow. Scale bar, 20 µm. c Three different double immunofluorescence images showing focal Aβ+ deposit surrounded by positive SgIII and CPE accumulations and the presence of SgIII and CPE in the same aberrant structures. Arrows indicate colocalization in yellow. Scale bar 20 µm

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