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Fig. 3 | Translational Neurodegeneration

Fig. 3

From: Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Fig. 3

Studying the avidity of RmAb158 to Aβ protofibrils. a SDS-PAGE showing a single band approximately at 150 kDa for RmAb158 and 50 kDa for its Fab fragment, R-Fab158. b Schematic representation of indirect Aβ ELISA setup where Aβ1-42 protofibrils are coated on the well surface, followed by binding of the generated Rmab158 or R-Fab158. c Indirect ELISA displaying the binding curves of RmAb158 and R-Fab158 to Aβ1-42 protofibrils. Strong binding of RmAb158 to Aβ protofibrils compared to R-Fab158 that demonstrates weak binding. Data are presented as mean ± SD, n = 2

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Translational Neurodegeneration

ISSN: 2047-9158

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