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Fig. 1 | Translational Neurodegeneration

Fig. 1

From: Neurofilament light and heterogeneity of disease progression in amyotrophic lateral sclerosis: development and validation of a prediction model to improve interventional trials

Fig. 1

Heterogeneity of disease progression rates and possible application of a prediction model. a The heterogeneity of disease progression rates in ALS, as shown by ALSFRS-R slopes of each study participant in the three cohorts of this study during the follow-up time. b The application of a prediction model in one patient receiving an efficient treatment. Note that without the use of a prediction model, the treatment effect (difference between the red and green lines) can hardly be differentiated from natural heterogeneity. Eventually, the use of the prediction model (yellow lines) reveals a significant slowdown of disease progression

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