Table 1 Eligibility criteria for admission in this review

Preclinical and clinical studies reporting noninvasive application of mechanical vibration-based approaches to impact AD pathology and/or related symptoms

Preclinical and clinical studies reporting the application of mechanical vibration-based approaches to impact physical and/or cognitive deficits in aged animal models or non-demented older adults (aged over 60 years)

Studies written in English

Reviews, conference papers, proceedings papers, editorials, and surveys

Studies reporting the use of mechanical waves to facilitate/interfere with drug/gene delivery into the brain

Studies in which mechanical stimulation is combined with other (unusual) interventions/activities (e.g., physical exercise)

Studies in which nonperiodic mechanical waves are used to stimulate the brain

Studies that evaluate the effect of mechanical stimulation in individuals suffering from cognitive decline derived from other diseases/conditions (e.g., stroke, ischemia, Parkinson’s disease)