From: Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
References | Samples/subjects | Conditions | DNA methylation changes |
---|---|---|---|
Tan et al. [42] | 5Â ml blood samples of patients with PD | PD | CpG-2 of SNCA is hypomethylated |
Cronk et al. [122] | C57Bl/6Â J MeCP2-null mice | Rett syndrome | MeCP2 regulates microglial responsiveness and inflammatory gene transcription |
McKinney et al. [83] | Postmortem orbital frontal cortices from 22 individuals (age > 60 years) | Brain aging | Ten of 26 CpG loci in BDNF are hypermethylated |
Tarale et al. [45] | Human neuroblastoma cell line | PD | PARK2 and PINK1 are hypermethylated |
Xie et al. [157] | Whole-blood samples from 506 aMCI patients | AD | Peripheral BDNF promoter methylation is elevated |
Gontier et al. [133] | Aged (18-month-old) male C57BL/6 mice | Brain aging | Decreased Tet2 expression and 5-hmC levels in the aged hippocampus |
Li et al. [8] | Individuals (Female: 47; Male: 54) | AD | Hypomethylated enhancers in the DSCAML1 gene that targets BACE1 |
Balasubramanian et al. [119] | Adult male Wistar rats | Mild traumatic brain injury | Hypermethylation at SOD2 promoter |
Li et al. [134] | Aged APPswe/PSEN1 double-transgenic mice | AD | Decreased expression of Tet2 |