Skip to main content

Table 1 Regulation of DNAm during neurodegeneration

From: Roles of physical exercise in neurodegeneration: reversal of epigenetic clock

References

Samples/subjects

Conditions

DNA methylation changes

Tan et al. [42]

5 ml blood samples of patients with PD

PD

CpG-2 of SNCA is hypomethylated

Cronk et al. [122]

C57Bl/6 J

MeCP2-null mice

Rett syndrome

MeCP2 regulates microglial responsiveness and inflammatory gene transcription

McKinney et al. [83]

Postmortem orbital frontal cortices from 22 individuals (age > 60 years)

Brain aging

Ten of 26 CpG loci in BDNF are hypermethylated

Tarale et al. [45]

Human neuroblastoma cell line

PD

PARK2 and PINK1 are hypermethylated

Xie et al. [157]

Whole-blood samples from 506 aMCI patients

AD

Peripheral BDNF promoter methylation is elevated

Gontier et al. [133]

Aged (18-month-old) male C57BL/6 mice

Brain aging

Decreased Tet2 expression and 5-hmC levels in the aged hippocampus

Li et al. [8]

Individuals (Female: 47; Male: 54)

AD

Hypomethylated enhancers in the DSCAML1 gene that targets BACE1

Balasubramanian et al. [119]

Adult male Wistar rats

Mild traumatic brain injury

Hypermethylation at SOD2 promoter

Li et al. [134]

Aged APPswe/PSEN1 double-transgenic mice

AD

Decreased expression of Tet2

  1. 5-hmC 5-hydroxymethylcytosine, AD Alzheimer’s disease, aMCI amnestic mild cognitive impairment, APP amyloid precursor protein, BACE1 β-site APP cleaving enzyme I, BDNF brain-derived neurotrophic factor, MeCP2 methyl-CpG-binding protein 2, PARK2 Parkin RBR E3 ubiquitin protein ligase, PD Parkinson’s disease, PINK1 PTEN-induced putative kinase 1, PSEN1 presenilin 1, SOD2 superoxide dismutase 2, Tet2 ten-eleven translocation methyl cytosine dioxygenases