| |
rEEC % (95%CI)
|
Awaji % (95%CI)
|
Gold Coast % (95%CI)
|
P values
|
|---|
|
Total patients
|
|
Sensitivitya
|
43.6 (40.8–46.5)
|
55.4 (52.5–58.3)
| |
<0.001
|
|
Specificitya
|
69.6 (47.0–85.9)
|
65.2 (42.8–82.8)
| |
<0.001
|
|
Sensitivityb
|
85.1 (82.9–87.1)
|
85.3 (83.2–87.3)
|
96.6 (95.3–97.5)
|
<0.001c
|
|
Specificityb
|
30.4 (14.1–53.0)
|
30.4 (14.1–53.0)
|
17.4 (5.7–39.5)
|
0.004c
|
|
Bulbar-onset
|
|
Sensitivitya
|
49.8 (44.0–55.7)
|
56.9 (51.0–62.6)
| |
<0.001
|
|
Sensitivityb
|
92.9 (89.2–95.5)
|
92.9 (89.2–95.5)
|
96.6 (93.7–98.3)
|
0.035c
|
|
Limb-onset
|
|
Sensitivitya
|
41.3 (38.0–44.8)
|
54.7 (51.3–58.0)
| |
<0.001
|
|
Specificitya
|
69.6 (47.0–85.9)
|
65.2 (42.8–82.8)
| |
<0.001
|
|
Sensitivityb
|
82.3 (79.5–84.7)
|
82.6 (79.9–85.1)
|
96.5 (95.0–97.6)
|
<0.001c
|
|
Specificityb
|
30.4 (14.1–53.0)
|
30.4 (14.1–53.0)
|
17.4 (5.7–39.5)
|
0.004c
|
|
Patients with EMG
|
|
Sensitivitya
|
38.1 (34.8–41.4)
|
54.1 (50.7–57.5)
| |
<0.001
|
|
Specificitya
|
75.0 (50.6–90.4)
|
70.0 (45.7–87.2)
| |
<0.001
|
|
Sensitivityb
|
84.5 (81.8–86.8)
|
84.8 (82.2–87.1)
|
98.6 (97.5–99.2)
|
<0.001c
|
|
Specificityb
|
30.0 (12.8–54.3)
|
30.0 (12.8–54.3)
|
15.0 (4.0–38.9)
|
0.018c
|
|
Patients without EMG
|
|
Sensitivitya
|
59.2 (53.4–64.7)
| | |
|
Specificitya
|
33.3 (1.8–87.5)
| | |
|
Sensitivityb
|
86.9 (82.5–90.4)
|
90.8 (86.9–93.7)
|
<0.001
|
|
Specificityb
|
33.3 (1.8–87.5)
|
33.3 (1.8–87.5)
|
0.333
|
- ALS amyotrophic lateral sclerosis, CI confidential interval, EMG electromyograph, rEEC revised El Escorial criteria
- a Only clinically definite or probable ALS were considered as positive findings
- b All diagnostic categories in rEEC and Awaji criteria were considered as positive findings
- c Awaji vs Gold Coast criteria
