Table 3 Diagnostic accuracy of ALS criteria
rEEC % (95%CI) | Awaji % (95%CI) | Gold Coast % (95%CI) | P values | |
|---|---|---|---|---|
Total patients | ||||
Sensitivitya | 43.6 (40.8–46.5) | 55.4 (52.5–58.3) | <0.001 | |
Specificitya | 69.6 (47.0–85.9) | 65.2 (42.8–82.8) | <0.001 | |
Sensitivityb | 85.1 (82.9–87.1) | 85.3 (83.2–87.3) | 96.6 (95.3–97.5) | <0.001c |
Specificityb | 30.4 (14.1–53.0) | 30.4 (14.1–53.0) | 17.4 (5.7–39.5) | 0.004c |
Bulbar-onset | ||||
Sensitivitya | 49.8 (44.0–55.7) | 56.9 (51.0–62.6) | <0.001 | |
Sensitivityb | 92.9 (89.2–95.5) | 92.9 (89.2–95.5) | 96.6 (93.7–98.3) | 0.035c |
Limb-onset | ||||
Sensitivitya | 41.3 (38.0–44.8) | 54.7 (51.3–58.0) | <0.001 | |
Specificitya | 69.6 (47.0–85.9) | 65.2 (42.8–82.8) | <0.001 | |
Sensitivityb | 82.3 (79.5–84.7) | 82.6 (79.9–85.1) | 96.5 (95.0–97.6) | <0.001c |
Specificityb | 30.4 (14.1–53.0) | 30.4 (14.1–53.0) | 17.4 (5.7–39.5) | 0.004c |
Patients with EMG | ||||
Sensitivitya | 38.1 (34.8–41.4) | 54.1 (50.7–57.5) | <0.001 | |
Specificitya | 75.0 (50.6–90.4) | 70.0 (45.7–87.2) | <0.001 | |
Sensitivityb | 84.5 (81.8–86.8) | 84.8 (82.2–87.1) | 98.6 (97.5–99.2) | <0.001c |
Specificityb | 30.0 (12.8–54.3) | 30.0 (12.8–54.3) | 15.0 (4.0–38.9) | 0.018c |
Patients without EMG | ||||
Sensitivitya | 59.2 (53.4–64.7) | |||
Specificitya | 33.3 (1.8–87.5) | |||
Sensitivityb | 86.9 (82.5–90.4) | 90.8 (86.9–93.7) | <0.001 | |
Specificityb | 33.3 (1.8–87.5) | 33.3 (1.8–87.5) | 0.333 | |