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Table 3 Diagnostic accuracy of ALS criteria

From: The Gold Coast criteria increases the diagnostic sensitivity for amyotrophic lateral sclerosis in a Chinese population

  rEEC % (95%CI) Awaji % (95%CI) Gold Coast % (95%CI) P values
Total patients
 Sensitivitya 43.6 (40.8–46.5) 55.4 (52.5–58.3)   <0.001
 Specificitya 69.6 (47.0–85.9) 65.2 (42.8–82.8)   <0.001
 Sensitivityb 85.1 (82.9–87.1) 85.3 (83.2–87.3) 96.6 (95.3–97.5) <0.001c
 Specificityb 30.4 (14.1–53.0) 30.4 (14.1–53.0) 17.4 (5.7–39.5) 0.004c
Bulbar-onset
 Sensitivitya 49.8 (44.0–55.7) 56.9 (51.0–62.6)   <0.001
 Sensitivityb 92.9 (89.2–95.5) 92.9 (89.2–95.5) 96.6 (93.7–98.3) 0.035c
Limb-onset
 Sensitivitya 41.3 (38.0–44.8) 54.7 (51.3–58.0)   <0.001
 Specificitya 69.6 (47.0–85.9) 65.2 (42.8–82.8)   <0.001
 Sensitivityb 82.3 (79.5–84.7) 82.6 (79.9–85.1) 96.5 (95.0–97.6) <0.001c
 Specificityb 30.4 (14.1–53.0) 30.4 (14.1–53.0) 17.4 (5.7–39.5) 0.004c
Patients with EMG
 Sensitivitya 38.1 (34.8–41.4) 54.1 (50.7–57.5)   <0.001
 Specificitya 75.0 (50.6–90.4) 70.0 (45.7–87.2)   <0.001
 Sensitivityb 84.5 (81.8–86.8) 84.8 (82.2–87.1) 98.6 (97.5–99.2) <0.001c
 Specificityb 30.0 (12.8–54.3) 30.0 (12.8–54.3) 15.0 (4.0–38.9) 0.018c
Patients without EMG
 Sensitivitya 59.2 (53.4–64.7)   
 Specificitya 33.3 (1.8–87.5)   
 Sensitivityb 86.9 (82.5–90.4) 90.8 (86.9–93.7) <0.001
 Specificityb 33.3 (1.8–87.5) 33.3 (1.8–87.5) 0.333
  1. ALS amyotrophic lateral sclerosis, CI confidential interval, EMG electromyograph, rEEC revised El Escorial criteria
  2. a Only clinically definite or probable ALS were considered as positive findings
  3. b All diagnostic categories in rEEC and Awaji criteria were considered as positive findings
  4. c Awaji vs Gold Coast criteria