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Fig. 1 | Translational Neurodegeneration

Fig. 1

From: Optimization of cerebral organoids: a more qualified model for Alzheimer’s disease research

Fig. 1

Commonly used animal- and cell-based AD models. Animal models, mostly rodent-based, can be divided into three categories: aging models, transgenic models, and models established by substance injections. Induced neurons or co-cultures of neurons and glial cells are commonly used as AD cell models but suffer from restrictions, such as the non-physiological top-to-bottom polar distribution of neuron-glial cells, and a lack of synaptic connections between cells. The 3D culture conditions may overcome these limitations

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