Fig. 1
From: Multivariable clinical-genetic model for predicting dyskinesia in early-onset Parkinson’s disease
ROC curves for prediction of LID incidence during the first 5 years of duration (a, b) and during the first 5 years of DRT (c, d), using two different models in the derivation (a, c) and the validation groups (b, d). Clinical variables included sex, onset age, duration, initial treatment, LEDD, initial symptoms, BMI, UPDRS-III, H&Y staging, hyposmia, and family history. Genetic variables included genotype data on 11 candidate SNPs. a Clinical model AUC = 0.714, 95%CI, 0.655–0.767; clinical-genetics model AUC = 0.864, 95%CI, 0.817–0.903; n = 279. b Clinical model AUC = 0.740, 95%CI, 0.657–0.811; clinical-genetics model AUC = 0.884, 95%CI, 0.817–0.932; n = 144. c Clinical model AUC = 0.710, 95%CI, 0.645–0.770; clinical-genetics model AUC = 0.798, 95%CI, 0.738–0.850; n = 232. d Clinical model AUC = 0.687, 95%CI, 0.585–0.777; clinical-genetics model AUC = 0.879, 95%CI, 0.798–0.936; n = 102