Associations of cerebrospinal fluid amyloidogenic nanoplaques with cytokines in Alzheimer’s disease

Table 3 Adjusted associations between nanoplaque levels and IL-8 and MIP-1α

	Model 1		Model 2
	β-coefficient (CI)	P	β-coefficient (CI)	P
Dependent variable: IL-8 pg/ml
CSF nanoplaques^a	−3.830 (−6.038; −1.622)	0.001	−3.536 (−5.821; −1.250)	0.003
Male sex	−0.802 (−3.376; 1.773)	0.538	− 1.071 (− 3.682; 1.540)	0.418
Age	−0.054 (− 0.214; 0.106)	0.505	− 0.029 (− 0.203; 0.144)	0.737
CDR-SOB	0.170 (− 0.390; 0.731)	0.548	0.144 (− 0.431; 0.720)	0.620
APOE ε4	−0.452 (− 1.818; 0.915)	0.513	− 0.373 (− 1.799; 1.054)	0.605
CSF Aβ₄₂ pg/ml			0.002 (−0.002; 0.007)	0.321
CSF P-tau pg/ml			0.018 (−0.015; 0.052)	0.285
Dependent variable: MIP-1α pg/ml
CSF nanoplaques^a	−0.083 (− 0.133; − 0.034)	0.001	−0.079 (− 0.127; − 0.031)	0.002
Male sex	0.049 (− 0.010; 0.107)	0.101	0.037 (− 0.018; 0.092)	0.180
Age	0.005 (0.002; 0.009)	0.006	0.005 (0.001; 0.009)	0.009
CDR-SOB	0.012 (−0.001; 0.025)	0.064	0.007 (−0.005; 0.019)	0.233
APOE ε4	0.030 (−0.001; 0.061)	0.058	0.023 (−0.007; 0.053)	0.128
CSF Aβ₄₂ pg/ml			0.000 (−0.000; 0.000)	0.486
CSF P-tau pg/ml			0.001 (0.001; 0.002)	< 0.001

Aβ amyloid-β, APOE apolipoprotein E, CI confidence interval, CDR-SOB Clinical Dementia Rating Scale Sum of Boxes, CSF cerebrospinal fluid, fseo frequency of single event occurrence per hour, IL-8 interleukin-8, MIP-1α macrophage inflammatory protein 1α, P-tau phosphorylated tau
^aLog (fseo). The β-coefficient denotes the degree of change in the dependent variable (IL-8 or MIP-1α) for a one-step change in the continuous predictor variables or the presence of the dichotomised predictor variables

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