Skip to main content
Fig. 7 | Translational Neurodegeneration

Fig. 7

From: Parkinson’s disease–associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy

Fig. 7

Mitochondria of VPS35D620N cells appear damaged under basal conditions and do not respond to CCCP. a, b Representative TEM micrographs of WT and VPS35D620N (clones 1 and 2) cells treated with DMSO (a) or 10 μM CCCP for 6 h (b). Mitochondria are highlighted in red. DGC, degradative compartment; G, Golgi apparatus; PM, plasma membrane. Scale bar, 1 μm. c Representative examples of the mitochondria categories I–V. d Quantification of the mitochondrial profile of WT or VPS35D620N (clones 1 and 2) cells treated with DMSO or 10 μM CCCP for 6 h. Statistical analyses were performed by two-way ANOVA followed by Tukey’s post-hoc test. n.s. non-significant, ****P < 0.001

Back to article page

Translational Neurodegeneration

ISSN: 2047-9158

Contact us