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Fig. 3 | Translational Neurodegeneration

Fig. 3

From: Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions

Fig. 3

Distribution of phosphorylated α-syn in the lumbar spinal cord after injection of different α-syn strains. a Immunohistochemistry for pSer129 α-syn demonstrated α-syn pathology in the spinal cord among different groups. High magnification showed that pSer129 α-syn in motor neurons was mainly located in the lumbar spinal cord. α-Syn aggregation was present in neurites (arrows) and in cell bodies (asterisks). Scale bar, 10 μm. bd Semi-quantitative analyses of pSer129 α-syn intensity (immunohistochemical staining) in the whole ventral part and areas of the lumbar spinal cord where motor neurons are mainly located (one-way ANOVA with Tukey’s multiple comparison tests, n = 3, *P < 0.05, **P < 0.01, ***P < 0.001). e Comparison between the ipsilateral and contralateral sides in the lumbar spinal cord in Strain B group. Scale bar, 50 μm. f Statistical analysis by unpaired t-test (n = 3, P > 0.05). Mean ± SD

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