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Fig. 2 | Translational Neurodegeneration

Fig. 2

From: Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies

Fig. 2

Schematic of the most common forms of alternative splicing. a Exon skipping. b Intron retention. c Alternative 5’ splice site (ss) selection. d Alternative 3’ ss selection. e Alternative polyadenylation (polyA) sites. f Mutually exclusive exons. Light blue boxes denote segments included in the final message, while green boxes denote segments excluded in the mature mRNA transcript. Dotted lines show the splicing pattern. Note: mechanisms are not mutually exclusive, and combinations can often occur.

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